Data report · 1,483 products · 169 categories

The Supplement Overpayment Report

Last reviewed Jul 2026

Across 169 supplement categories, the most expensive product costs a median 6.7x more per clinically effective dose than the cheapest fully-disclosed option in the same category, and every category shows at least a 2x spread. In 63% of categories, that cheapest fully-disclosed, decent-evidence product matched or beat the most expensive one on our 0-100 execution score. And across the 22 categories that contain a proprietary-blend product with a computable effective-dose cost, 43 of those 43 blend products cost more than the cheapest fully-disclosed competitor.

The supplement aisle prices things the way perfume does: the number on the tag says very little about what is in the bottle. We score every product in our catalog on cost per clinically effective dose, so we can measure exactly how little. This report aggregates 1,483 scored products across 169 supplement categories, from creatine monohydrate to vitamin D3 to magnesium glycinate. It names no brands, on purpose. The pattern is the point.

What the catalog shows

  • The median price spread is 6.7x. Within a single supplement category, comparing the cheapest fully-disclosed, decent-evidence product to the single most expensive product, both at the clinically effective dose. Every one of the 169 categories shows at least a 2x spread, 68% show 5x or more, and 34% show 10x or more. The widest spread in the catalog is roughly 90x.
  • The budget pick matched or beat the priciest product in 63% of categories (107 of 169) on our overall execution score, which grades dosing, third-party purity verification, value, and label transparency. In the other 37% the priciest product scored higher, so this is a majority pattern, not a rule.
  • The proprietary-blend premium is universal in our catalog. 43 of 43 blend products with a computable cost per effective dose cost more than the cheapest fully-disclosed product in their category, across the 22 categories where the comparison exists. A further 21 blend products do not disclose enough dose information to compute the cost at all.
  • Paying the most does not reliably buy independent testing. In 37% of categories (63 of 169), the most expensive product carries no third-party testing certification we could verify. Meanwhile the cheapest fully-disclosed, decent-evidence pick is third-party tested in 52% of categories.

The honest reading

Two things are true at once, and we would rather you hear both from us. First, our overall execution score includes a value pillar that by construction rewards a low cost per effective dose, which flatters cheap products in the headline comparison above. So we also ran the same comparison on the three pillars that have nothing to do with price: dosing and form, purity verification, and transparency. On those alone, the cheapest disclosed pick matched or beat the priciest product in 31% of categories. The most expensive product in a category really does tend to be a well-made product.

Second, and this is the finding we consider the report's core: that tendency is far too weak to price-shop by. The median within-category correlation between cost per effective dose and the non-price quality pillars is 0.30 (computed across 168 categories with five or more priceable products). A correlation that size means price explains only a small fraction of the quality differences between products. In our view, the label and the certification database predict what you are getting; the price tag mostly predicts what you will pay. Where a premium product earns its premium, our scores say so, product by product.

Method and data snapshot

Computed from the 1,571 scored products and 176 supplement categories in the Supplement Scored catalog, data last reviewed July 2026. Excluded from the analysis: 4 categories on a per-serving cost model (multi-ingredient blend powders have no finished-product clinical dose), 3 categories with fewer than three priceable products or no fully-disclosed baseline, and any product whose cost per clinically effective dose is not computable from its label. That leaves 1,483 products across 169 analyzed categories.

Per category, we compare the cheapest fully-disclosed (no proprietary blend) product with an evidence grade of C- or better against the single most expensive product in the same category, both on cost per clinically effective dose - the cost of taking the amount the research actually used, not the price per bottle. "Matched or beat" means the budget pick's execution score was greater than or equal to the priciest product's. Execution scores are our methodology-driven opinion under a published, deterministic rubric; they are reconstructible from public label, certification, and price data using our methodology, and the underlying per-product scores are published as machine-readable JSON. Figures on this page are recomputed from the live catalog on every site build, and this is a within-catalog analysis using our own rubric as the quality signal, not an independent clinical audit.

Every analyzed category, by price spread

Costs are per day at the clinically effective dose. "Budget pick held up" means the cheapest fully-disclosed, decent-evidence product scored at or above the category's most expensive product on our execution rubric. No brands are named here; each category links to its scorecard, where every product and score is public.

CategoryProductsCheapest disclosedMost expensiveSpreadBudget pick held up
Hyaluronic Acid10$0.08/day$7.18/day89.8xyes
Elderberry10$0.05/day$2.87/day57.4xyes
Vitamin C10$0.03/day$1.53/day51.0xyes
Panax Ginseng (Korean Red Ginseng)10$0.03/day$1.52/day50.7xno
DHEA10$0.01/day$0.50/day50.0xno
Multivitamin (General Adult)14$0.03/day$1.33/day44.3xyes
Iron (Bisglycinate)8$0.02/day$0.83/day41.5xyes
GABA (Gamma-Aminobutyric Acid)10$0.02/day$0.83/day41.5xyes
Prenatal Multivitamin10$0.05/day$2.00/day40.0xno
Glucomannan9$0.07/day$2.66/day38.0xyes
Vitamin D3 + K211$0.03/day$1.10/day36.7xyes
L-Theanine9$0.08/day$2.66/day33.3xyes
Tart Cherry10$0.22/day$6.50/day29.5xno
N-Acetyl Cysteine (NAC)10$0.07/day$2.00/day28.6xyes
L-Carnitine10$0.10/day$2.54/day25.4xyes
Vitamin E8$0.02/day$0.50/day25.0xno
Chromium Picolinate8$0.03/day$0.72/day24.0xyes
Red Yeast Rice11$0.06/day$1.39/day23.2xyes
Mass Gainer12$0.47/day$9.44/day20.1xyes
Folate / Methylfolate5$0.02/day$0.40/day20.0xyes
Mucuna Pruriens10$0.03/day$0.58/day19.3xno
Bovine Colostrum8$0.12/day$2.23/day18.6xyes
DIM (Diindolylmethane)8$0.06/day$1.08/day18.0xno
Thiamine (Vitamin B1)6$0.01/day$0.18/day18.0xno
Vitamin D310$0.02/day$0.35/day17.5xyes
Glycine8$0.07/day$1.17/day16.7xyes
Taurine10$0.06/day$1.00/day16.7xyes
Chlorella9$0.43/day$6.94/day16.1xno
Choline Bitartrate10$0.02/day$0.32/day16.0xyes
Calcium + Vitamin D310$0.04/day$0.62/day15.5xyes
Creatine Monohydrate10$0.11/day$1.67/day15.2xyes
Iodine9$0.03/day$0.45/day15.0xyes
N-Acetyl Glucosamine (NAG)8$0.08/day$1.20/day15.0xyes
L-Citrulline10$0.09/day$1.33/day14.8xyes
Inositol10$0.15/day$2.20/day14.7xyes
Cinnamon8$0.03/day$0.44/day14.7xyes
Quercetin10$0.05/day$0.73/day14.6xno
Pterostilbene7$0.04/day$0.55/day13.8xno
Spirulina10$0.22/day$3.00/day13.6xno
NMN (Nicotinamide Mononucleotide)8$0.27/day$3.66/day13.6xyes
Tribulus Terrestris8$0.09/day$1.21/day13.4xno
Milk Thistle (Silymarin)10$0.08/day$1.07/day13.4xno
BCAAs (Branched-Chain Amino Acids)10$0.12/day$1.60/day13.3xyes
Garlic Extract10$0.06/day$0.80/day13.3xno
Red Raspberry Leaf9$0.07/day$0.93/day13.3xyes
Saffron8$0.10/day$1.27/day12.7xyes
Ginkgo Biloba10$0.04/day$0.50/day12.5xyes
Echinacea8$0.23/day$2.74/day11.9xyes
Psyllium Husk10$0.06/day$0.68/day11.3xyes
Ginger (Zingiber officinale, rhizome extract)8$0.04/day$0.45/day11.3xno
Resveratrol10$0.18/day$2.00/day11.1xyes
Vitamin A10$0.02/day$0.22/day11.0xno
5-HTP (5-Hydroxytryptophan)9$0.08/day$0.86/day10.8xyes
Rhodiola Rosea8$0.15/day$1.60/day10.7xyes
Vitamin B67$0.03/day$0.32/day10.7xyes
Magnesium Glycinate15$0.09/day$0.93/day10.3xyes
Tongkat Ali10$0.10/day$1.00/day10.0xno
Fiber Supplement8$0.40/day$3.91/day9.8xyes
MSM (Methylsulfonylmethane)10$0.08/day$0.78/day9.8xno
Moringa10$0.10/day$0.97/day9.7xyes
Ergothioneine7$0.14/day$1.33/day9.5xyes
Beetroot Powder9$0.59/day$5.60/day9.5xyes
TMG (Trimethylglycine / Betaine Anhydrous)6$0.05/day$0.47/day9.4xyes
Hawthorn Berry8$0.10/day$0.87/day8.7xno
Green Tea Extract (EGCG)10$0.13/day$1.13/day8.7xyes
Fenugreek10$0.13/day$1.10/day8.5xno
Maca Root10$0.08/day$0.67/day8.4xyes
Probiotic (General Multi-Strain)10$0.30/day$2.50/day8.3xyes
Agmatine Sulfate8$0.10/day$0.83/day8.3xno
Schisandra10$0.10/day$0.83/day8.3xyes
Vitamin B128$0.05/day$0.40/day8.0xno
Saccharomyces Boulardii8$0.10/day$0.80/day8.0xno
Copper7$0.04/day$0.32/day8.0xno
Cranberry (PAC-Standardized)9$0.10/day$0.79/day7.9xno
Acetyl-L-Carnitine10$0.12/day$0.93/day7.8xno
Valerian Root9$0.09/day$0.67/day7.4xyes
Glucosamine Sulfate9$0.12/day$0.89/day7.4xyes
Chondroitin Sulfate10$0.13/day$0.93/day7.2xyes
Lion's Mane Mushroom9$0.15/day$1.07/day7.1xyes
Stinging Nettle10$0.12/day$0.85/day7.1xno
Manganese6$0.04/day$0.28/day7.0xyes
Sunflower Lecithin7$0.10/day$0.70/day7.0xyes
Urolithin A6$0.72/day$4.93/day6.8xyes
Cod Liver Oil10$0.24/day$1.63/day6.8xyes
Fish Oil (Omega-3)12$0.14/day$0.94/day6.7xyes
Alpha-Lipoic Acid (ALA)9$0.12/day$0.78/day6.5xno
Beta-Alanine8$0.10/day$0.65/day6.5xyes
Akkermansia muciniphila5$0.33/day$2.13/day6.5xno
D-Chiro-Inositol6$0.20/day$1.28/day6.4xyes
Lemon Balm7$0.16/day$1.00/day6.3xyes
Magnesium Malate9$0.13/day$0.80/day6.2xyes
L-Arginine10$0.18/day$1.10/day6.1xyes
Turmeric / Curcumin11$0.11/day$0.67/day6.1xno
Astaxanthin9$0.13/day$0.78/day6.0xyes
Phosphatidylserine9$0.50/day$3.00/day6.0xyes
Glutathione8$0.30/day$1.80/day6.0xyes
Kava8$0.20/day$1.18/day5.9xno
L-Glutamine8$0.12/day$0.70/day5.8xno
Vitamin K26$0.05/day$0.29/day5.8xyes
Cordyceps9$0.22/day$1.25/day5.7xyes
Reishi Mushroom9$0.18/day$1.00/day5.6xyes
Myo-Inositol7$0.15/day$0.83/day5.5xno
Olive Leaf Extract9$0.17/day$0.94/day5.5xyes
Boswellia Serrata8$0.28/day$1.53/day5.5xyes
Zinc8$0.05/day$0.27/day5.4xno
Melatonin8$0.05/day$0.27/day5.4xyes
Pycnogenol9$0.14/day$0.75/day5.4xno
Selenium10$0.04/day$0.21/day5.3xyes
Huperzine A10$0.08/day$0.42/day5.3xyes
Bacopa Monnieri10$0.16/day$0.83/day5.2xyes
Alpha-GPC9$0.29/day$1.50/day5.2xno
Boron9$0.06/day$0.30/day5.0xno
Vitex (Chasteberry)7$0.10/day$0.50/day5.0xno
Spermidine8$0.50/day$2.50/day5.0xno
Artichoke Leaf Extract (Cynara scolymus / Cynara cardunculus)8$0.08/day$0.40/day5.0xno
Digestive Enzymes8$0.17/day$0.84/day4.9xyes
D-Mannose8$0.25/day$1.18/day4.7xyes
Dandelion Root (Taraxacum officinale)8$0.10/day$0.45/day4.5xno
Lutein + Zeaxanthin8$0.25/day$1.11/day4.4xno
Ashwagandha10$0.16/day$0.70/day4.4xyes
Calcium Alpha-Ketoglutarate (Ca-AKG)6$0.42/day$1.83/day4.4xyes
L-Tyrosine10$0.07/day$0.30/day4.3xyes
Bromelain9$0.20/day$0.85/day4.3xyes
Vitamin B Complex8$0.12/day$0.50/day4.2xno
Marshmallow Root8$0.12/day$0.50/day4.2xno
Astragalus8$0.12/day$0.50/day4.2xno
Policosanol10$0.10/day$0.41/day4.1xno
Black Cohosh (Actaea racemosa / Cimicifuga racemosa)10$0.14/day$0.57/day4.1xno
Biotin9$0.05/day$0.20/day4.0xyes
CoQ10 (Ubiquinol)8$0.25/day$0.99/day4.0xyes
Shilajit8$0.40/day$1.58/day4.0xyes
Peppermint Oil (Enteric-Coated)8$0.17/day$0.67/day3.9xno
Benfotiamine6$0.17/day$0.67/day3.9xyes
Plant Protein Blend11$0.79/day$3.09/day3.9xyes
Methylene Blue5$0.26/day$1.00/day3.8xyes
Sulforaphane8$0.21/day$0.80/day3.8xno
Magnesium Citrate5$0.10/day$0.38/day3.8xyes
Chaga Mushroom10$0.25/day$0.95/day3.8xyes
Collagen Peptides13$0.38/day$1.40/day3.7xyes
PQQ (Pyrroloquinoline Quinone)8$0.27/day$0.93/day3.4xno
Nattokinase10$0.16/day$0.55/day3.4xno
Casein Protein11$0.57/day$1.94/day3.4xno
Betaine HCl (Betaine Hydrochloride)7$0.10/day$0.34/day3.4xno
Apigenin8$0.11/day$0.37/day3.4xno
TUDCA (Tauroursodeoxycholic Acid)6$0.60/day$2.01/day3.3xyes
Nicotinamide Riboside (NR)9$0.50/day$1.67/day3.3xyes
Riboflavin (Vitamin B2)6$0.12/day$0.40/day3.3xyes
Evening Primrose Oil9$0.20/day$0.65/day3.3xyes
Whey Protein Isolate9$0.72/day$2.33/day3.2xyes
Slippery Elm (Ulmus rubra inner bark)7$0.06/day$0.19/day3.2xyes
Calcium (Standalone)12$0.15/day$0.47/day3.1xno
Saw Palmetto7$0.27/day$0.82/day3.0xyes
Pumpkin Seed Oil10$0.10/day$0.30/day3.0xyes
Magnesium L-Threonate8$1.00/day$2.98/day3.0xyes
Algal Oil (Vegan Omega-3)8$0.24/day$0.71/day3.0xno
Holy Basil (Tulsi)10$0.17/day$0.50/day2.9xyes
Krill Oil9$0.47/day$1.37/day2.9xyes
HMB (Beta-Hydroxy-Beta-Methylbutyrate)9$0.30/day$0.83/day2.8xyes
SAMe (S-Adenosylmethionine)8$0.47/day$1.27/day2.7xyes
Gymnema Sylvestre7$0.10/day$0.27/day2.7xno
Palmitoylethanolamide (PEA)8$0.30/day$0.80/day2.7xno
Fisetin7$1.47/day$3.83/day2.6xyes
Berberine5$0.36/day$0.93/day2.6xyes
MCT Oil10$0.45/day$1.10/day2.4xyes
Electrolyte Powders13$0.75/day$1.82/day2.4xno
Protein Powder10$1.03/day$2.26/day2.2xno
Black Seed Oil (Nigella sativa, thymoquinone-containing)8$0.32/day$0.69/day2.2xyes
Citicoline8$0.28/day$0.60/day2.1xyes
EPA Fish Oil3$0.55/day$1.10/day2.0xno

FAQ

Do expensive supplements work better than cheap ones?
Not reliably, in our data. Across 169 supplement categories, the cheapest fully-disclosed, decent-evidence product matched or beat the most expensive product on our overall execution score in 63% of categories. The most expensive product did hold an edge on the non-price quality pillars in most categories, but the median within-category correlation between price and those pillars was only 0.30, weak enough that price alone is a poor screening tool. In our view the label, dose, and third-party testing status predict far more than the price tag.
Do proprietary blends cost more?
In our catalog, yes, without exception: 43 of the 43 proprietary-blend products with a computable cost per effective dose (across 22 categories) cost more than the cheapest fully-disclosed product in their category. Another 21 blend products hide the dose so completely that a cost per effective dose cannot even be computed.
How do I avoid overpaying for a supplement?
Compare cost per clinically effective dose, not price per bottle. Check that the label discloses every ingredient amount (no proprietary blends), that the dose matches what the research actually used, and whether an independent lab (USP, NSF, ConsumerLab, BSCG, Informed Sport) has verified the product. Every scorecard on this site runs that math for you.
How were these numbers computed?
Every figure is computed from Supplement Scored's live product catalog (1,483 priceable products across 169 supplement categories, data last reviewed July 2026) using cost per clinically effective dose, proprietary-blend status, third-party testing status, and our published 0-100 execution rubric. Figures are recomputed from the catalog every time the site builds, so this page stays in step with the scorecards. The full methodology is public, and every underlying score is reconstructible from label, certification, and price data.

Cite this report

Figures are computed across every scored product in the catalog and update as the catalog grows. Reuse is welcome with attribution to Supplement Scored and a link to this page.

Supplement Scored. "The Supplement Overpayment Report." https://www.supplementscored.com/reports/supplement-overpayment/

Related reading: the true cost per effective dose of every major supplement, why proprietary blends are a red flag, and how to choose supplements.

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before starting any supplement regimen.