Heart & Cardiovascular

If heart health is on your mind, these are the names worth knowing. CoQ10, omega-3, fish oil, and cardiovascular support supplements.

Fish Oil (Omega-3)

Fish Oil (Omega-3)

Heart health, triglyceride reduction, inflammation, joint support, brain health

Strong Evidence12 products
CoQ10 (Ubiquinol)

CoQ10 (Ubiquinol)

Heart failure support, statin-induced myopathy relief, cellular energy production, antioxidant protection

Likely Effective8 products
Krill Oil

Krill Oil

Provides phospholipid-bound omega-3 fatty acids (EPA and DHA) for cardiovascular, joint, and anti-inflammatory support with potentially better absorption than fish oil.

Likely Effective10 products
EPA Fish Oil

EPA Fish Oil

Lowers triglycerides and reduces major adverse cardiovascular events in high-risk patients, with strongest evidence at high doses (1,000-4,000 mg EPA daily).

Strong Evidence10 products
Algal Oil (Vegan Omega-3)

Algal Oil (Vegan Omega-3)

DHA and EPA omega-3s from a vegan source - brain health, cardiovascular protection, inflammation reduction

Likely Effective8 products
Psyllium Husk

Psyllium Husk

Soluble fiber that improves bowel regularity, lowers LDL cholesterol, and moderates post-meal blood glucose spikes. One of the few supplements with an FDA-approved health claim for heart disease risk reduction.

Strong Evidence10 products
Cod Liver Oil

Cod Liver Oil

Combined source of omega-3 fatty acids (EPA/DHA), vitamin A, and vitamin D

Likely Effective10 products
Reds Powder

Reds Powder

Convenient polyphenol and antioxidant backstop for adults who eat almost no berries or fruit - not a fruit replacement, and the whole-product evidence is thinner than the marketing suggests. The one semi-defensible mechanism (beet nitrate lowering blood pressure) needs standalone clinical doses that blends rarely disclose or deliver.

Mixed Evidence11 products
Taurine

Taurine

Blood pressure support, exercise endurance, cardiovascular and metabolic health

Likely Effective10 products
L-Carnitine

L-Carnitine

Exercise recovery, post-MI cardiovascular support, modest fat-loss adjunct, and male fertility

Mixed Evidence10 products
Astaxanthin

Astaxanthin

Skin photoprotection, eye fatigue, oxidative stress

Mixed Evidence9 products
Resveratrol

Resveratrol

Modest improvements in insulin sensitivity, endothelial function, and systolic blood pressure in metabolic and cardiovascular populations

Mixed Evidence10 products
Citicoline

Citicoline

Attention, focus, age-related memory support, and cognitive recovery after ischemic insults

Mixed Evidence8 products
Garlic Extract

Garlic Extract

Modest blood pressure reduction in hypertensives, small LDL cholesterol drop, mild antiplatelet effect, possible cold-frequency reduction

Likely Effective10 products
Nattokinase

Nattokinase

Modest blood pressure reduction in hypertensives, fibrinolytic biomarker effects, theoretical clot prevention

Weak Evidence10 products
Policosanol

Policosanol

Marketed for cholesterol lowering and cardiovascular support, but the LDL-lowering claim has failed every independent replication trial since 2006.

Weak Evidence10 products
Red Yeast Rice

Red Yeast Rice

LDL cholesterol reduction (only when the product actually contains monacolin K, which functions as a low-dose statin)

Mixed Evidence11 products
Spirulina

Spirulina

Modest improvements in lipid panel, blood pressure, exercise endurance, and inflammatory markers from a nutrient-dense microalgae

Mixed Evidence10 products
Chlorella

Chlorella

Modest LDL and blood pressure support, mucosal immune (sIgA) signal in athletes

Weak Evidence9 products
Moringa

Moringa

Whole-leaf nutrient density, with early signals for blood glucose, lipids, and inflammation in small RCTs

Weak Evidence10 products
Olive Leaf Extract

Olive Leaf Extract

Mild blood pressure reduction, modest triglyceride and LDL improvements, antioxidant support

Mixed Evidence9 products
L-Arginine

L-Arginine

Nitric oxide precursor for vasodilation, mild ED support, and amino acid pool

Mixed Evidence10 products
TMG (Trimethylglycine / Betaine Anhydrous)

TMG (Trimethylglycine / Betaine Anhydrous)

Homocysteine lowering via methylation support, with modest power-output and muscle endurance signal in resistance-trained men

Mixed Evidence6 products
Sulforaphane

Sulforaphane

Activation of the Nrf2 antioxidant defense pathway and phase II detoxification enzymes

Weak Evidence8 products
Pterostilbene

Pterostilbene

Polyphenol with better oral bioavailability than resveratrol; small human RCT base for blood pressure and as a co-ingredient in NAD+ stacks

Weak Evidence8 products
Hawthorn Berry

Hawthorn Berry

Adjunct cardiovascular support in chronic heart failure (NYHA II-III) under physician supervision; modest signal for mild hypertension

Mixed Evidence8 products
Alpha-Lipoic Acid (ALA)

Alpha-Lipoic Acid (ALA)

Studied for nerve comfort in diabetic peripheral neuropathy under physician care, antioxidant cofactor that regenerates glutathione and vitamins C and E, and modest support for body weight and metabolic markers.

Mixed Evidence9 products
Gymnema Sylvestre

Gymnema Sylvestre

Sweet-taste suppression that can blunt sugar cravings short-term, plus modest support for blood sugar already in the normal range

Mixed Evidence7 products
Glucomannan

Glucomannan

Soluble fiber from konjac root that expands in the stomach with water, supports satiety before meals, and modestly lowers LDL cholesterol. EFSA approved an Article 13 health claim for body weight reduction at 3g/day in three divided doses with water before meals, in the context of an energy-restricted diet. Trial evidence on weight is mixed: short-term studies favor glucomannan, but the largest meta-analysis found no statistically significant overall effect.

Mixed Evidence9 products
Artichoke Leaf Extract (Cynara scolymus / Cynara cardunculus)

Artichoke Leaf Extract (Cynara scolymus / Cynara cardunculus)

Supports healthy cholesterol levels already in normal range and supports digestive comfort, especially after fatty meals

Mixed Evidence8 products
Pycnogenol

Pycnogenol

Supports leg comfort and venous tone in chronic venous insufficiency, healthy blood flow via endothelial function, and skin elasticity at 100-360mg/day of the trademarked Pycnogenol extract.

Mixed Evidence9 products
Black Seed Oil (Nigella sativa, thymoquinone-containing)

Black Seed Oil (Nigella sativa, thymoquinone-containing)

Supports normal lipid balance, blood pressure within the normal range, glycemic markers, and modest weight management; thymoquinone is the studied bioactive

Mixed Evidence8 products
Cinnamon

Cinnamon

Modest support for fasting blood glucose already in the normal range, with Ceylon cinnamon strongly preferred over Cassia for chronic daily use because of coumarin content

Mixed Evidence8 products

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products discussed on this page are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before starting any supplement regimen.