Energy & Performance

For the gym, the trail, or just getting through the afternoon. Pre-workouts, CoQ10, beetroot, electrolytes, and athletic performance supplements.

CoQ10 (Ubiquinol)

CoQ10 (Ubiquinol)

Heart failure support, statin-induced myopathy relief, cellular energy production, antioxidant protection

Likely Effective8 products
Beetroot Powder

Beetroot Powder

Improves exercise endurance, reduces blood pressure, and lowers the oxygen cost of submaximal exercise via dietary nitrate conversion to nitric oxide.

Likely Effective10 products
Pre-Workout Formulas

Pre-Workout Formulas

Enhanced exercise performance through clinically dosed caffeine, citrulline, beta-alanine, and creatine

Mixed Evidence10 products
Electrolyte Powders

Electrolyte Powders

Replaces sodium, potassium, and other electrolytes lost during prolonged exercise, heat exposure, or acute illness

Likely Effective13 products
Taurine

Taurine

Blood pressure support, exercise endurance, cardiovascular and metabolic health

Likely Effective10 products
L-Carnitine

L-Carnitine

Exercise recovery, post-MI cardiovascular support, modest fat-loss adjunct, and male fertility

Mixed Evidence10 products
Acetyl-L-Carnitine

Acetyl-L-Carnitine

Diabetic peripheral neuropathy, cognitive aging support, mitochondrial energy in brain and nerve tissue

Mixed Evidence10 products
Spirulina

Spirulina

Modest improvements in lipid panel, blood pressure, exercise endurance, and inflammatory markers from a nutrient-dense microalgae

Mixed Evidence10 products
Phosphatidylserine

Phosphatidylserine

Modest support for age-related memory complaints; cortisol blunting in trained athletes at higher doses

Mixed Evidence9 products
Tart Cherry

Tart Cherry

Exercise recovery (DOMS, strength, oxidative stress) and modest sleep quality improvements

Mixed Evidence10 products
L-Arginine

L-Arginine

Nitric oxide precursor for vasodilation, mild ED support, and amino acid pool

Mixed Evidence10 products
Cordyceps

Cordyceps

Aerobic capacity and exercise tolerance, immune modulation, anti-fatigue support

Mixed Evidence9 products
Shilajit

Shilajit

Traditional Ayurvedic resin with limited but real evidence for testosterone support in older or subfertile men; most other claims are speculative

Mixed Evidence8 products
Agmatine Sulfate

Agmatine Sulfate

Sold heavily in pre-workouts for 'pumps' and as a neuropathic pain or mood aid; the marketing is far ahead of the human evidence on every one of those claims

Mixed Evidence8 products
NMN (Nicotinamide Mononucleotide)

NMN (Nicotinamide Mononucleotide)

Raises blood NAD+ levels; preliminary signals for insulin sensitivity, physical function, and aerobic capacity in midlife and older adults

Weak Evidence8 products
Nicotinamide Riboside (NR)

Nicotinamide Riboside (NR)

NAD+ elevation as a cellular metabolism support; downstream functional benefits in humans remain unconfirmed

Weak Evidence9 products
TMG (Trimethylglycine / Betaine Anhydrous)

TMG (Trimethylglycine / Betaine Anhydrous)

Homocysteine lowering via methylation support, with modest power-output and muscle endurance signal in resistance-trained men

Mixed Evidence6 products
Apigenin

Apigenin

Plant flavone from chamomile and parsley, studied in cells and rodents for relaxation, NAD+/CD38 modulation, and longevity; no high-quality human RCTs on the standalone supplement

Weak Evidence8 products
MCT Oil

MCT Oil

Rapid ketone fuel, modest body composition support when substituted for long-chain fats, and a studied adjunct in mild Alzheimer's cognitive decline

Mixed Evidence10 products
L-Glutamine

L-Glutamine

Fuel for intestinal cells and immune cells; studied for gut barrier support, IBS-D symptoms, sickle cell crisis reduction, and recovery in specific clinical settings

Mixed Evidence8 products
Spermidine

Spermidine

Marketed as a natural polyamine that supports cellular renewal (autophagy); the human evidence for downstream cognitive or longevity benefits is small and the largest RCT missed its primary endpoint

Weak Evidence8 products
Pterostilbene

Pterostilbene

Polyphenol with better oral bioavailability than resveratrol; small human RCT base for blood pressure and as a co-ingredient in NAD+ stacks

Weak Evidence8 products
Beta-Alanine

Beta-Alanine

Supports exercise capacity in high-intensity efforts lasting 1-4 minutes by raising intramuscular carnosine and buffering acid build-up

Likely Effective9 products
PQQ (Pyrroloquinoline Quinone)

PQQ (Pyrroloquinoline Quinone)

Mitochondrial cofactor marketed for cellular energy and cognitive support; small, mostly industry-funded human trials at 20mg/day

Weak Evidence8 products
Astragalus

Astragalus

Traditional immune and qi tonic with a long Chinese herbal history; modern human RCT evidence is limited and most positive trials are chemotherapy or kidney-disease adjuncts, not stand-alone immune support in healthy adults.

Weak Evidence8 products
Magnesium Malate

Magnesium Malate

General magnesium repletion with a malic acid pairing often used for morning dosing, energy, and fibromyalgia-related muscle discomfort

Mixed Evidence9 products
HMB (Beta-Hydroxy-Beta-Methylbutyrate)

HMB (Beta-Hydroxy-Beta-Methylbutyrate)

Supports lean body mass preservation and recovery, with the strongest signals in older adults, during bed rest, in novice trainees, and during caloric deficit

Likely Effective9 products

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products discussed on this page are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before starting any supplement regimen.