Weight Management

No supplement does the heavy lifting here, but a few have real research behind them. Green tea extract, berberine, fiber supplements, and metabolic support supplements.

Green Tea Extract (EGCG)

Green Tea Extract (EGCG)

Antioxidant support, modest fat oxidation enhancement, and cardiovascular health benefits via EGCG catechins

Mixed Evidence10 products
Berberine

Berberine

Blood sugar regulation, cholesterol reduction, metabolic health, weight management

Likely Effective5 products
Psyllium Husk

Psyllium Husk

Soluble fiber that improves bowel regularity, lowers LDL cholesterol, and moderates post-meal blood glucose spikes. One of the few supplements with an FDA-approved health claim for heart disease risk reduction.

Strong Evidence10 products
Meal Replacement Shake

Meal Replacement Shake

A convenient, calorie-controlled stand-in for a meal when you would otherwise skip eating or grab fast food - useful for short-term weight control and convenience, not a health upgrade over a balanced plate of real food.

Mixed Evidence11 products
L-Carnitine

L-Carnitine

Exercise recovery, post-MI cardiovascular support, modest fat-loss adjunct, and male fertility

Mixed Evidence10 products
Fenugreek

Fenugreek

Modest blood sugar and HbA1c reductions; mixed signals for testosterone, libido, and lactation support

Mixed Evidence10 products
Chromium Picolinate

Chromium Picolinate

Modest blood sugar / HbA1c support in type 2 diabetes; small effects on weight and carbohydrate craving

Weak Evidence8 products
Inositol

Inositol

PCOS metabolic and ovulatory support, gestational diabetes prevention, anxiety and panic disorder

Likely Effective10 products
Myo-Inositol

Myo-Inositol

Supports normal ovarian function, insulin sensitivity, and cycle regularity in women with PCOS, with secondary use for IVF egg quality and gestational diabetes prevention

Likely Effective7 products
D-Chiro-Inositol

D-Chiro-Inositol

Insulin pathway and ovarian support, almost always better delivered as part of a 40:1 myo-inositol to D-chiro-inositol ratio than as DCI alone

Likely Effective6 products
MCT Oil

MCT Oil

Rapid ketone fuel, modest body composition support when substituted for long-chain fats, and a studied adjunct in mild Alzheimer's cognitive decline

Mixed Evidence10 products
Alpha-Lipoic Acid (ALA)

Alpha-Lipoic Acid (ALA)

Studied for nerve comfort in diabetic peripheral neuropathy under physician care, antioxidant cofactor that regenerates glutathione and vitamins C and E, and modest support for body weight and metabolic markers.

Mixed Evidence9 products
Gymnema Sylvestre

Gymnema Sylvestre

Sweet-taste suppression that can blunt sugar cravings short-term, plus modest support for blood sugar already in the normal range

Mixed Evidence7 products
Glucomannan

Glucomannan

Soluble fiber from konjac root that expands in the stomach with water, supports satiety before meals, and modestly lowers LDL cholesterol. EFSA approved an Article 13 health claim for body weight reduction at 3g/day in three divided doses with water before meals, in the context of an energy-restricted diet. Trial evidence on weight is mixed: short-term studies favor glucomannan, but the largest meta-analysis found no statistically significant overall effect.

Mixed Evidence9 products
Dandelion Root (Taraxacum officinale)

Dandelion Root (Taraxacum officinale)

Traditional digestive bitter and mild diuretic; supports digestive comfort and normal urinary flow

Weak Evidence8 products
Black Seed Oil (Nigella sativa, thymoquinone-containing)

Black Seed Oil (Nigella sativa, thymoquinone-containing)

Supports normal lipid balance, blood pressure within the normal range, glycemic markers, and modest weight management; thymoquinone is the studied bioactive

Mixed Evidence8 products
Cinnamon

Cinnamon

Modest support for fasting blood glucose already in the normal range, with Ceylon cinnamon strongly preferred over Cassia for chronic daily use because of coumarin content

Mixed Evidence8 products

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products discussed on this page are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before starting any supplement regimen.